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All products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.
BPC-157 + TB-500 Overview
The BPC-157 + TB-500 blend combines two synthetic peptides studied for their signaling pathway interactions. BPC-157 is known for its potential effects on molecular signaling, structural remodeling, and collagen organisation, while TB-500 (synthetic thymosin beta-4, CAS 77591-33-4) is associated with epithelial modeling, angiogenesis, and extracellular matrix dynamics. Each constituent has been studied individually in laboratory and preclinical research contexts; the studies cited on this page did not examine the finished blend.
History
The concept of the BPC-157 + TB-500 blend stems from parallel lines of peptide research tracing back to foundational discoveries in molecular biology. BPC-157, deriving from a natural protein fragment in gastric tissue, was first synthesized to investigate its signaling and remodeling effects on structural and epithelial systems. Meanwhile, Thymosin β-4 (Tβ4)—supplied in synthetic form as TB-500—originated from the discovery of thymosins in the 1960s by Allan L. Goldstein and colleagues, leading to interest in Tβ4’s role in extracellular matrix dynamics and pathway modeling.
BPC-157 Structure
CAS #: 137525-51-0
Molecular Formula: C62H98N16O22
Molecular Weight: 1419.556 g/mol
PubChem ID: 9941957
TB-500 Structure
CAS #: 77591-33-4
Molecular Formula: C212H350N56O78S
Molecular Weight: 4963.5 g/mol
PubChem ID: 16132341
Research Findings
BPC-157 and TB-500 have been studied in structural, vascular, epithelial, and systemic models, with research exploring their effects on tendon-to-bone interface modeling, collagen organization, angiogenesis, molecular migration, and systemic signaling. These findings highlight their roles in matrix dynamics, vascular pathways, and pathway activity in preclinical settings.
Key Areas of Research:
- Structural: Tendon-to-bone, collagen, matrix
- Vascular: Angiogenesis, nitric oxide, remodeling
- Epithelial: Migration, signaling, matrix
- Systemic: Gastric, survival, pathway dynamics
Together, these findings suggest broad experimental applications for BPC-157 and TB-500 across multiple biological pathways. Their individually reported activity in collagen synthesis, vascular formation, cell migration, and systemic signaling provides a foundation for research into molecular remodeling, pathway dynamics, and experimental biology; these findings relate to the individual constituents rather than the finished blend.
References
Goldstein A.L., Hannappel E., Kleinman H.K. (2005). Trends Mol Med, 11(9):421–9. PubMed ID 16099219.
Chang C.H. et al. (2011). J Appl Physiol (1985), 110(3):774–80. PubMed ID 21030672.
Hsieh M.J. et al. (2017). J Mol Med (Berl), 95(3):323–333. PubMed ID 27847966.
Huang T. et al. (2015). Drug Des Devel Ther, 9:2485–99. PubMed ID 25995620.
Sikiric P. et al. (2018). Curr Pharm Des, 24(18):1990–2001. PubMed ID 29879879.
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Our Process
Precision Lyophilization
Each batch is freeze-dried and sealed for stability until reconstitution.
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