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TB-500
TB-500 5mg research vial, product photo
Made in the USA Ships from Atlanta, GA
COA Pending

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TB-500 Peptide

2 for 1 active now

CAS #: 77591-33-4

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Retail Price$140
Your Price$70Per vial: $35
Vials2 vials
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$70

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Research Use Only

All products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.

TB-500 Peptide Overview

TB-500 peptide — also written TB500 or TB 500 — is supplied for laboratory research involving matrix-remodeling and vascular-signaling pathways. Research has focused on its potential influence on matrix remodeling, angiogenesis, and molecular migration in preclinical and laboratory models. TB-500 is of particular interest in investigations involving connective tissue, structural dynamics, and extracellular matrix pathways.

TB-500 is also supplied as one constituent of two multi-compound Medicina Labs research formulations, GLOW and KLOW.

History

Thymosin beta-4 was characterised during research into thymus-derived peptides begun in the 1960s by Allan L. Goldstein and colleagues. The material supplied here as TB-500 is specified by CAS 77591-33-4, which identifies the synthetic N-acetylated 43-amino-acid thymosin beta-4 sequence (INN: timbetasin), so the sequence can be studied as a defined synthetic material. Since its development, it has been investigated across models of angiogenesis, structural dynamics, and molecular migration, with continued interest in the actin-binding activity associated with the parent thymosin beta-4 sequence.

TB-500 Structure

CAS #: 77591-33-4
Molecular Formula: C212H350N56O78S
Molecular Weight: 4963.5 g/mol
PubChem ID: 16132341
Amino Acid Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser (43 residues)

Research Findings

TB-500 has been studied in structural, vascular, epithelial, and systemic models, with research exploring its roles in collagen organization, extracellular matrix remodeling, angiogenesis, molecular migration, and pathway activity in preclinical settings.

Key Areas of Research:

  • Structural: Collagen, matrix, tendon/ligament
  • Vascular: Angiogenesis, nitric oxide, remodeling
  • Epithelial: Migration, signaling, matrix
  • Systemic: Signaling, viability, pathway dynamics

Together, these findings suggest broad experimental utility for TB-500 across multiple biological pathways. By engaging structural, vascular, and epithelial signaling processes, TB-500 provides a versatile platform for investigating molecular remodeling, actin-associated cell migration, and pathway dynamics in laboratory settings.

References

Malinda K.M. et al. (1997). Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells. FASEB J, 11(6):474–81.

Smart N. et al. (2007). Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 445(7124):177–82.

Bock-Marquette I. et al. (2004). Nature, 432(7016):466–72. PubMed ID 15565145.

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Common Questions

Purity is measured by HPLC (High-Performance Liquid Chromatography), which separates and quantifies each component in a sample. The result is reported as a percentage on the Certificate of Analysis (COA), along with the chromatogram, for every batch.
All our peptides are tested by independent third-party labs and consistently achieve 99.4%+ purity. Every product ships with a Certificate of Analysis so you can verify the exact purity of your specific batch.
Orders ship within 24 hours. Standard ground shipping is free on every order and typically arrives within 3-5 business days. UPS 2nd Day Air (2 business days) is available at checkout for $19.95, and is complimentary when your merchandise subtotal after discounts is $200 or more. We ONLY ship to addresses within the United States — U.S. territories are served case-by-case upon verification.
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TB-500 5mg $70